Abstract
DURING investigation of patients with Klinefelter's syndrome, autoradiography of chromosome preparations was carried out in a number of cases. The main object of this investigation was to determine the number and nature of late replicating chromosomes, and the results agree with the assumption that one middle group chromosome replicates late in the S phase in individuals with forty-seven (XXY) and forty-six (XX) chromosomes, two in those with forty-eight (XXXY) chromosomes and three in those with forty-nine (XXXXY) chromosomes. In addition, it was found that in many instances the late replicating chromosomes had a peculiar internal labelling pattern.
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References
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FRØLAND, A. Internal Asynchrony in Late Replicating X Chromosomes. Nature 213, 512–513 (1967). https://doi.org/10.1038/213512a0
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DOI: https://doi.org/10.1038/213512a0
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