Abstract
DESPITE a long history of the clinical use of nitroglycerine as a powerful coronary vasodilator, very little is known about the basic mechanism by which this agent relaxes vascular smooth muscles. As a first step to search into the underlying mechanism of this relaxant action, the effect of this compound on the electrical activity of the isolated guinea-pig taenia coli was examined using the sucrose-gap technique, and this was compared with the actions of several other representative vasodilators, such as papaverine, theophylline and adenosine.
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IMAI, S., TAKEDA, K. Effects of Vasodilators on the Isolated Taenia Coli of the Guinea-pig. Nature 213, 509–511 (1967). https://doi.org/10.1038/213509a0
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DOI: https://doi.org/10.1038/213509a0
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