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Synergistic Action of Antibodies: Detection of Circulating Antileucocyte Antibodies after Skin Transplantation

Abstract

LEUCOCYTE isoantibodies, which appear after skin homo-transplantation in rabbits and rats, cannot usually be detected by simple agglutination. This report describes a method for demonstrating these isoantibodies, which is based on the synergistic action of two antibody systems1,2, and which is also suitable for leucocyte typing. In this method donor leucocytes are agglutinated by the joint action of two different antibodies, each used in a subagglutinating titre.

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References

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GABRIEL, M., HANNA, N. & NELKEN, D. Synergistic Action of Antibodies: Detection of Circulating Antileucocyte Antibodies after Skin Transplantation. Nature 213, 499–500 (1967). https://doi.org/10.1038/213499a0

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  • DOI: https://doi.org/10.1038/213499a0

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