Abstract
SINCE the demonstration in the rabbit of specific immuno-logical tolerance when 6-mercaptopurine was administered together with the antigen bovine serum albumin1, numerous examples of tolerance induced by immuno-suppressive drugs have been demonstrated2. This phenomenon of drug-induced tolerance is a particularly favourable system for the analysis of the fundamental and still incompletely understood problem of specific immunological unreactivity, but so far it has received little attention in this connexion.
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AISENBERG, A., WILKES, B. Immunological Tolerance induced by Cyclophosphamide assayed by Plaque Spleen Cell Method. Nature 213, 498–499 (1967). https://doi.org/10.1038/213498a0
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DOI: https://doi.org/10.1038/213498a0
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