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Suppression of Antibody Production by Phytohaemagglutinin

Nature volume 213, pages 495–496 (1967)Cite this article

Abstract

THE in vitro effect of phytohaemagglutinin (PHA) on small lymphocytes from the peripheral blood is now well known1,2, and a limited number of studies of the effect of this substance in vivo have been made in man3,4 and laboratory rodents5–7. Calne and his colleagues8 reported the use of PHA to augment the immunosuppressive effect of ‘Imuran’. We have studied the effect of PHA on the immune response of rats to foreign red blood cells, and the preliminary results of our experiments are reported here.

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References

  1. Carstairs, K., Lancet, i, 829 (1962).

  2. Elves, M. W. in Current Research in Leukaemia (edit. by Hayhoe, F. G. J.) (Cambridge University Press, 1965).

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  3. Humble, J. G., Lancet, i, 1345 (1964).

  4. Fleming, A. F., Lancet., ii, 647 (1964).

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  8. Calne, R. Y., Wheeler, J. R., and Hurn, B. A. L., Brit. Med. J., ii, 154 (1965).

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  1. The Charles Salt Research Centre, The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire

    MICHAEL W. ELVES

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  1. MICHAEL W. ELVES
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ELVES, M. Suppression of Antibody Production by Phytohaemagglutinin. Nature 213, 495–496 (1967). https://doi.org/10.1038/213495a0

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