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Dual Localization of β-Glucuronidase in Endoplasmic Reticulum and in Lysosomes

Abstract

Acid hydrolases are not exclusively lysosomal enzymes as indicated by the specific case of β-glucuronidase. This enzyme is a membrane protein found in the endoplasmic reticulum and in the lysosomes of the cell.

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References

  1. Novikoff, A. B. in The Cell (edit. by Bracket, J., and Mirsky, A. E.), 2, 423 (Academic Press, New York, 1961).

    Book  Google Scholar 

  2. deDuve, C., Pressman, B. C., Gianetto, R., Wattiaux, R., and Appelmans, F., Biochem. J., 60, 604 (1955).

    Article  CAS  Google Scholar 

  3. Fishman, W. H., Goldman, S. S., and Green, S., J. Histochem. Cytochem., 12, 239 (1964).

    Article  CAS  PubMed  Google Scholar 

  4. Friedenwald, J. S., and Becker, B., J. Cell Comp. Physiol., 31, 303 (1948).

    Article  CAS  PubMed  Google Scholar 

  5. Fishman, W. H., and Baker, J. R., J. Histochem. Cytochem., 4, 570 (1956).

    Article  PubMed  Google Scholar 

  6. Sabitini, D. D., Benesch, K., and Barnett, R. J., J. Cell Biol., 17, 19 (1963).

    Article  Google Scholar 

  7. Fishman, W. H., Nakajima, Y., Anstiss, C., and Green, S., J. Histochem. Cytochem., 12, 298 (1964).

    Article  CAS  PubMed  Google Scholar 

  8. Fishman, W. H., and Goldman, S. S., J. Histochem. Cytochem., 13, 441 (1965).

    Article  CAS  PubMed  Google Scholar 

  9. Beaver, D. L., Anatomical Record, 146, 47 (1963).

    Article  CAS  PubMed  Google Scholar 

  10. Collins, D. H., Ghadially, F. N., and Meachim, G., Ann. Rheum. Dis., 24, 123 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Pugh, D., and Walker, P. G., J. Histochem. Cytochem., 9, 105 (1961).

    Article  CAS  PubMed  Google Scholar 

  12. Van Lancker, J. L., and Holtzer, R. L., Lab. Invest., 12, 102 (1963).

    CAS  PubMed  Google Scholar 

  13. Walkinshaw, C. H., and Van Lancker, J. L., Lab. Invest., 13, 513 (1964).

    CAS  PubMed  Google Scholar 

  14. Gottlieb, L. I., Fausto, N., and Van Lancker, J. L., J. Biol. Chem., 239, 555 (1964).

    CAS  PubMed  Google Scholar 

  15. Van Lancker, J. L., Fed. Proc., 23, 1050 (1964).

    CAS  Google Scholar 

  16. Burstone, M. S., Enzyme Histochemistry (Academic Press, 1962).

    Google Scholar 

  17. Shnitka, T. K., and Seligman, A. M., J. Histochem. Cytochem., 9, 514 (1961).

    Article  Google Scholar 

  18. Holt, S. J. in General Cytochemical Methods (edit. by Danielli, J. F.), 1, 375 (Academic Press, 1958).

    Google Scholar 

  19. DeLellis, R., and Fishman, W. H., J. Histochem. Cytochem., 13, 297 (1965).

    Article  CAS  PubMed  Google Scholar 

  20. Lehrer, G. M., and Orenstein, L., J. Biophys. Biochem. Cytol., 6, 399 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Novikoff, A. B. in Lysosomes (edit. by de Reuck, A. V. S., and Cameron, M. P.) (Little, Brown and Co., Boston, 1963).

    Google Scholar 

  22. Sandberg, A. A., and Slaunwhite, W. R., J. Clin. Invest., 44, 694 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Roberts, K. D., Bandi, R., Calvin, H. I., Drucker, W. D., and Lieberman, S., J. Amer. Chem. Soc., 86, 958 (1964).

    Article  CAS  Google Scholar 

  24. Baulieu, E. E., Corpechot, C., Dray, F., Embiozzi, R., Lebeau, M. C., Mauvais-Jarvis, P., and Robel, P., Rec. Prog. Horm. Res., 21, 411 (1965).

    CAS  PubMed  Google Scholar 

  25. Lipsett, M. B., Wilson, H., Kirschner, M. A., Korenman, S. O., Fishman, L. M., Sarfaty, G. A., and Bardin, C. W., Rec. Prog. Horm. Res., 22, 245 (1966).

    CAS  PubMed  Google Scholar 

  26. Fishman, W. H., Chemistry of Drug Metabolism (C. C. Thomas, Publisher, 1962).

    Google Scholar 

  27. Maki, T. Sato, To., and Sato, Ta., Tohoku J. Exp. Med., 77, 179 (1962).

    Article  CAS  PubMed  Google Scholar 

  28. Green, D. in The Mitochondrion (edit. by Lehninger, A. L.) (John Wiley and Sons, New York, 1964).

    Book  Google Scholar 

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FISHMAN, W., GOLDMAN, S. & DeLELLIS, R. Dual Localization of β-Glucuronidase in Endoplasmic Reticulum and in Lysosomes. Nature 213, 457–460 (1967). https://doi.org/10.1038/213457a0

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