Abstract
WITH overproduction of bilirubin due to haemolytic anaemia, a minor though significant fraction of the plasma bilirubin may exhibit a direct diazo reaction in the absence of detectable liver dysfunction1. If the direct-reacting material is in fact conjugated bilirubin2, this would support the concept3 that the secretion of conjugated pigment from the hepatic cell into the bile is a rate limiting step in bilirubin transport across the liver. Chemical identification of this direct-reacting pigment fraction as conjugated bilirubin is difficult, however, because the amounts available for analysis are very small, the extraction procedures are semi-quantitative4,5 and part of the unconjugated pigment may react directly with the diazo reagent1,6.
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SNYDER, A., SATTERLEE, W., ROBINSON, S. et al. Conjugated Plasma Bilirubin in Jaundice caused by Pigment Overload. Nature 213, 93 (1967). https://doi.org/10.1038/213093a0
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DOI: https://doi.org/10.1038/213093a0
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