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Substrate Hydrophobic Groups and the Maximal Rate of Enzyme Reactions

Nature volume 213, pages 42–44 (1967)Cite this article

Abstract

The maximum rate (Vm) of certain enzyme reactions is increased as much as two to three times by a single additional carbon atom in a “chemically inert” hydrophobic region of the substrate molecule

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References

  1. Hofstee, B. H. J., J. Biol. Chem., 207, 219 (1954).

    CAS  PubMed  Google Scholar 

  2. Hofstee, B. H. J., J. Biol. Chem., 199, 365 (1952).

    CAS  PubMed  Google Scholar 

  3. Hofstee, B. H. J., Biochim. Biophys. Acta, 24, 211 (1957).

    Article  CAS  Google Scholar 

  4. Hofstee, B. H. J., J. Pharm. Exp. Ther., 123, 108 (1958).

    CAS  Google Scholar 

  5. Hofstee, B. H. J., Biochim. Biophys. Acta, 32, 182 (1959).

    Article  CAS  Google Scholar 

  6. Hofstee, B. H. J., J. Histochem. Cytochem., 12, 700 (1964).

    Article  CAS  Google Scholar 

  7. Miles, J. L., and Canady, W. J., Abstr. Fed. Proc., 22 (2), Part I, 244 (1963).

    Google Scholar 

  8. Foster, R. J., and Coahran, D. R., Abstr. Fed. Proc., 22 (2), Part I, 245 (1963).

    Google Scholar 

  9. Dixon, G. H., and Neurath, H., J. Biol. Chem., 225, 1049 (1957).

    CAS  PubMed  Google Scholar 

  10. Dixon, M., and Webb, E. C., Enzymes (Academic Press Inc., New York, 1958 and 1964).

    Google Scholar 

  11. Nelson, G. H., Miles, J. L., Canady, W. J., Arch. Biochem. Biophys., 96, 545 (1962).

    Article  CAS  Google Scholar 

  12. Miles, L., Robinson, D. A., and Canady, W. J., J. Biol. Chem., 238 (9), 2932 (1963).

    CAS  PubMed  Google Scholar 

  13. Jones, J. B., Kunitake, T., Niemann, C., and Hein, G. E., J. Amer. Chem. Soc., 87 (8), 1777 (1965).

    Article  CAS  Google Scholar 

  14. Hein, G. E., and Niemann, C., J. Amer. Chem. Soc., 84, 4495 (1962).

    Article  Google Scholar 

  15. Becker, E. L., Fukutu, T. R., Boone, B., Canham, D. C., and Boger, E., Biochem., 2, 72 (1963).

    Article  CAS  Google Scholar 

  16. Hofstee, B. H. J., Arch. Biochem. Biophys., 78, 188 (1958).

    Article  CAS  Google Scholar 

  17. Hein, G. E., Niemann, C., Proc. U.S. Nat. Acad. Sci., 47(9), 1341 (1961).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Palo Alto Medical Research Foundation, Palo Alto, California

    BAREND H. J. HOFSTEE

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  1. BAREND H. J. HOFSTEE
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HOFSTEE, B. Substrate Hydrophobic Groups and the Maximal Rate of Enzyme Reactions. Nature 213, 42–44 (1967). https://doi.org/10.1038/213042a0

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