Abstract
PLASMA ultrafiltrate is thought to contain polyphosphates which prevent the nucleation of calcium salts on collagen. Under physiological conditions, these substances are thought to be inactivated by alkaline phosphatase, and so do not interfere with nucleation in bone tissue. We have tested the efficiency of several polyphosphates in preventing the skeletal deposition of strontium-85 in experimental animals. In a series of experiments, groups of ten albino Sprague–Dawley rats (200 g) or ASL mice (20 g) were injected intraperitoneally with 1 µC. of strontium-85 free of carrier.
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References
Fleish, H., and Neuman, W. F., Amer. J. Physiol., 200, 1296 (1961).
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BATES, T., SMITH, H. Influence of Polyphosphates on Retention of Radioactive Strontium in Rat and Mouse. Nature 212, 925–926 (1966). https://doi.org/10.1038/212925b0
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DOI: https://doi.org/10.1038/212925b0
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