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Autosomal Trisomy in a Discordant Monozygotic Twin

Abstract

TURPIN et al.1 investigated a patient with Turner's syndrome who was found to have an apparently normal twin brother. Analysis of blood groups, plasma proteins and secretor status showed that they were probably monozygotic (P = 0.0075), and reciprocal transplants of skin tissue showed no signs of rejection after 78 days2. Chromosome analysis revealed an XO karyotype in the patient and an XY sex chromosome constitution in the normal brother. Since then, five other cases of monozygotic twins with discordant karyotypes have been described3–7. This communication describes a case of autosomal trisomy in an amorphous monozygotic twin.

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References

  1. Turpin, R., Lejeune, J., Lafourcade, J., Chigot, P. L., and Salmon, C., C.R. Acad. Sci., Paris, 252, 2945 (1961).

    CAS  Google Scholar 

  2. Lejeune, J., and Turpin, R., C.R. Acad. Sci., Paris, 252, 3148 (1961).

    CAS  Google Scholar 

  3. Lejeune, J., Lafourcade, J., Scharer, K., de Wolff, E., Salmon, C., Haines, M., and Turpin, R., C.R. Acad. Sci., Paris, 254, 4404 (1962).

    CAS  Google Scholar 

  4. Bruins, J. W., Bolhuis, J. van, Bijlsma, J. B., and Nijenhuis, L. E., Proc. Eleventh Intern. Cong. Genet., The Hague, 307 (1963).

  5. Dent, T., and Edwards, J. H., Proc. Eleventh Intern. Cong. Genet., The Hague, 304 (1963).

  6. Mikkelsen, M., Froland, A., and Elleberg, J., Cytogenetics, 2, 86 (1963).

    Article  CAS  Google Scholar 

  7. Benirschke, K., and Sullivan, M. M., Human Chromosome Newsletter, 15, 3 (1965).

    Google Scholar 

  8. Harnden, D. G., Brit. J. Exp. Pathol., 41, 31 (1960).

    CAS  Google Scholar 

  9. Benirschke, K., Obst. and Gyn., 14, 72 (1959).

    CAS  Google Scholar 

  10. Lejeune, J., Second Intern. Conf. on Congenital Malformations, New York, 68 (1964).

    Google Scholar 

  11. Schatz, F., (1887), cited in ref. 9.

  12. Richart, R., and Benirschke, K., Amer. J. Obst. and Gyn., 86, 329 (1963).

    Article  CAS  Google Scholar 

  13. Pfeifer, R. A., Schellong, G., and Kosenow, W., Klin. Wehnschr., 20, 1058 (1962).

    Article  Google Scholar 

  14. El-Alfi, O. S., Powell, H. C., and Biesle, J. J., Lancet, i, 700 (1963).

  15. Stalder, G. R., Buhler, E. M., and Weber, J. R., Lancet, i, 1379 (1963).

  16. Jacobs, P. A., Harnden, D. G., Buckton, K. E., Court Brown, W. M., King, M. J., McBride, J. A., Macgregor, T. N., and Maclean, N., Lancet, i, 1183 (1961).

  17. Smith, D. W., Amer. J. Obst. and Gyn., 90, 1055 (1964).

    Article  Google Scholar 

  18. Sandberg, A. A., Ishihara, I., and Crosswhite, L. H., Blood, 24, 716 (1964).

    CAS  PubMed  Google Scholar 

  19. Ruffie, J., Bierme, R., Ducos, J., Colombies, P., Salles-Meurlan, A. M., and Senbrail, A., Nouvelle Rev. Franç. d'Hematol., 4, 719 (1964).

    CAS  Google Scholar 

  20. Szulman, A., New England J. Med., 272, 811 (1965).

    Article  CAS  Google Scholar 

  21. Carr, D. H., Obst. and Gyn. (in the press).

  22. Willis, R. A., The Borderland of Embryology and Pathology, 448 (Butterworths, London. 1962).

    Google Scholar 

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KERR, M., RASHAD, M. Autosomal Trisomy in a Discordant Monozygotic Twin. Nature 212, 726–727 (1966). https://doi.org/10.1038/212726b0

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