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Mechanism for the Stimulation of Breathing produced by Ammonium Chloride

Nature volume 212, pages 711–713 (1966)Cite this article

Abstract

THE stimulant action of ammonium chloride on respiration was originally ascribed to the acidaemia which this salt is known to produce1,2. The alleged mechanism, at least by implication, was the stimulation of the chemo-receptors sensitive to acidaemia2. Anichkov3 and Joels and Neil4 were unable to demonstrate such an effect of ammonium chloride on the perfused carotid sinus region. Later, other workers5,6 concluded that the stimulation of respiration was the result of an action of ammonium chloride on certain areas of the central nervous system, because they obtained a stimulation of respiration after intracisternal injection of small quantities of this salt.

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References

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Chelsea College of Science and Technology, London, S.W.3

    J. A. DIMSDALE & J. H. BOTTING

Authors
  1. J. A. DIMSDALE
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  2. J. H. BOTTING
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DIMSDALE, J., BOTTING, J. Mechanism for the Stimulation of Breathing produced by Ammonium Chloride. Nature 212, 711–713 (1966). https://doi.org/10.1038/212711a0

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  • DOI: https://doi.org/10.1038/212711a0

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