Abstract
To explain the diabetogenic action of alloxan it is necessary to decide whether it is specifically taken up by the beta cells. Investigations of rats and toadfish have shown no specific uptake, and recent attempts to explain the mode of action of alloxan are based on its non-selective distribution1. We have investigated the distribution of alloxan-2-14C in mice by whole body autoradiography and micro-autoradiography and have found an accumulation in the islet tissue.
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References
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HAMMARSTRÖM, L., ULLBERG, S. Specific Uptake of Labelled Alloxan in the Pancreatic Islets. Nature 212, 708–709 (1966). https://doi.org/10.1038/212708a0
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DOI: https://doi.org/10.1038/212708a0
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