Abstract
THE application of hypertonic solutions speeds the appearance of clinical signs of cellular dehydration in proportion to the impermeability of the cellular membrane. Intravenous infusion of hypertonic saline, which remains effectively in the extracellular fluid space, stimulates cellular dehydration more intensely than an equivalent amount of urea, which readily penetrates cell membranes1,2. Rapid intravenous application of a hypertonic solution of sodium chloride brings about a hypertonic expansion of the physiologically active part of the extracellular fluid space3,4. There is evidence that intravenous loading with strongly hypertonic salt solutions is partially dependent on the mean arterial blood pressure if the renal function is not or is only slightly affected.
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References
Peters, J. P., New Engl. J. Med., 239, 353 (1948).
Wolf, A. V., Amer. J. Physiol., 161, 75 (1950).
McCance, R. A., and Widdowson, E. M., Acta Paediat., 46, 337 (1957).
Mertz, D. P., Klin. Wschr., 39, 903, 942 (1961).
Mertz, D. P., Die Extracelluläre Flüssigkeit (Biochemie und Klinik) (G. Thieme, Stuttgart, 1962).
Roe, J. H., Epstein, J. H., and Goldstein, N. P., J. Biol. Chem., 178, 839 (1949).
Czok, G., Kreienberg, W., and Mertz, D., Klin. Wschr., 30, 227 (1952).
Fisher, R. A., and Yates, F., Statistical Tables for Biological, Agricultural and Medical Research, fifth ed. (Oliver and Boyd, Edinburgh, 1957).
Riecker, G., Klin. Wschr., 35, 1158 (1957).
Adolph, E. F., Barker, J. P., and Hoy, P. A., Amer. J. Physiol., 178, 538 (1954).
Kerpel-Fronius, E., Pathologie und Klinik des Salz- und Wasserhaushaltes (Verl. Akad. Wtssensch., Budapest, 1959).
Black, D. A. K., Platt, R., and Stanbury, S. W., Clin. Sci., 9, 205 (1950).
Crawford, B., and Ludemann, H., J. Clin. Invest., 30, 1456 (1951).
Birchard, W. H., and Rosenbaum, J. D., Strauss, M. B., J. App. Physiol., 6, 22 (1953).
Papper, S., Saxon, L., Rosenbaum, J. D., Cohen, H. W., J. Lab. Clin. Med., 47, 776 (1956).
Holland, B. C., and Stead, E. A., Arch. Intern. Med., 88, 571 (1951).
Fourman, P., and Leeson, P. M., in Ciba Colloquia on Ageing, 4, 36 (J. and A. Churchill, London, 1958).
Verney, E. B., Lancet, ii, 1237, 1295 (1957).
Gilman, A., Amer. J. Physiol., 120, 323 (1937).
Holmes, J. H., and Gregersen, H. J., Amer. J. Physiol., 162, 326, 338 (1950).
Green, D. M., Wedell, H. G., Wald, M. H., and Learned, B., Circulation, 6, 919 (1952).
Mertz, D. P., Klin. Wschr., 44, 233, 244 (1966).
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MERTZ, D. Increased Tolerance to Intravenous Hypertonic Saline in Patients with Essential Hypertension. Nature 212, 1245–1247 (1966). https://doi.org/10.1038/2121245a0
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DOI: https://doi.org/10.1038/2121245a0
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