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Methaemoglobin Formation by Mycoplasma gallisepticum: the Role of Hydrogen Peroxide

Abstract

Mycoplasma gallisepticum, the agent responsible for common respiratory disease of turkeys, has been shown to agglutinate turkey erythrocytes1. During the course of investigations of a neurotropic strain of this organism (S6) which produces encephalitis associated with cerebral arteritis2, it was observed that incubation of a suspension of M. gallisepticum with washed turkey erythrocytes at 37° C caused the cells to become dark brown. Washed mycoplasmas enclosed in dialysis tubing also caused browning of erythrocyte suspensions and converted turkey and human haemoglobin to a brown solution which exhibited the spectral characteristics of methaemoglobin.

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THOMAS, L., BITENSKY, M. Methaemoglobin Formation by Mycoplasma gallisepticum: the Role of Hydrogen Peroxide. Nature 210, 963–964 (1966). https://doi.org/10.1038/210963a0

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