Abstract
AT one time, tumour viruses were believed to be species-specific, but tumour induction in vivo and cell transformation in vitro have made this concept inapplicable to experimental situations. Rous sarcoma virus will not only induce tumours in the original host and other avian species but will also cause in vivo and in vitro malignant transformation of mammalian cells. The induction of sarcomata in Old World non-human primates by Rous sarcoma virus preparations of the Carr-Zilber and Schmidt-Ruppin strains has been reported by four research groups1–5. In most of the in vivo experiments with primates ‘tissue minces’ from Rous sarcoma virus-induced chicken sarcomata were used for inoculation and the published reports gave no clear indication that the tumours were truly invasive and/or metastasizing.
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DEINHARDT, F. Neoplasms induced by Rous Sarcoma Virus in New World Monkeys. Nature 210, 443 (1966). https://doi.org/10.1038/210443a0
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DOI: https://doi.org/10.1038/210443a0
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