Further Evidence of Enhanced Tumour Destruction with Combined Laser Energy and Chemotherapy

Abstract

A PREVIOUS article¹ has reported on the significant increase in the tumoricidal effect of laser energy when combined with a course of chemotherapy. In the previous study, multiple pulses of ruby laser (6,943 Å) were used on Cloudman S-91 melanomata in CDF₁ mice, and cyclophosphamide was used as the chemotherapeutic agent. This communication reports a similar experiment in which neodymium laser energy (10,600 Å) was used, on the same tumour–host system with the same chemotherapeutic agent. It will be seen that the substitution of a neodymium laser for the ruby laser does not significantly effect the increased oncolytic properties of the combination therapy.