Abstract
THE existence of host defence mechanisms which operate against autochthonous cancer has been suspected for many years, and the possibility has been suggested that such resistance might depend on mechanisms similar to those which bring about homograft and heterograft rejection1,2. This presupposes that the host is able to recognize its own tumour cells as foreign and to react so as to inhibit them, perhaps by way of specific immunological mechanisms. Several authors have presented evidence from transplantation and serological studies which suggests that tumour cells are antigenically different from normal cells of the tumour-bearing host in which they arise3.
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REINER, J., SOUTHAM, C. Effect of Immunosuppression on First-generation Isotransplantation of Chemically Induced Tumours in Mice. Nature 210, 429–430 (1966). https://doi.org/10.1038/210429a0
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DOI: https://doi.org/10.1038/210429a0
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