Abstract
Sweet and Hilleman1 detected SV40 in seed stocks of adenoviruses, types 1–7, and Gerber et al.2 reported the presence of viable SV40 in formalinized adenovirus vaccines. Yang and Melnick3 described SV40 contamination of both adenovirus stock and vaccine. Such contaminations were attributed to the SV40 flora in many of the ‘normal’ monkey kidney cell cultures used for propagation of adenovirus. The report presented here describes the isolation of a poxvirus contaminant from a seed stock of adenovirus type 12. The poxvirus had been propagated by us in undetected form through many passages of the adenovirus in HEp-2 cells.
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HUXSOLL, D., POLLARD, M. Isolation of a Poxvirus from Stock Type 12 Adenovirus. Nature 209, 1157 (1966). https://doi.org/10.1038/2091157a0
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DOI: https://doi.org/10.1038/2091157a0
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