Abstract
Josimovich and MacLaren1 purified a substance from human placentas which cross-reacted immunologically with antiserum to human growth hormone in Ouchter-lony's double-diffusion system. Moreover, they detected this substance in the blood and urine of pregnant women, thereby raising the possibility that it might be a new placental hormone. Investigation of the physiological role of this substance has been hampered by the limited supply of material. The relatively easy method outlined here yields substantially greater quantities of this substance than could be obtained by the previously described purification from fresh-frozen placentas2.
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References
Josimovich, J. B., and MacLaren, J. A., Endocrinology, 71, 209 (1962).
Friesen, H., Endocrinology, 76, 369 (1965).
Astwood, E. B., in Ciba Found. Coll. Endocrinology, Bioassay of Anterior Pituitary Hormones, 5, 74, edit. by Wolstenholme, G. E. W. (Little, Brown and Co., Boston, 1953).
Bates, R. W., Garrison, M. M., and Cornfield, J., Endocrinology, 73, 217 (1963).
Bradley, T. R., and Clarke, P. M., J. Endocrinol., 14, 28 (1956).
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FRIESEN, H. Further Purification and Characterization of a Placental Protein with Immunological Similarity to Human Growth Hormone. Nature 208, 1214–1215 (1965). https://doi.org/10.1038/2081214a0
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DOI: https://doi.org/10.1038/2081214a0
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