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A Common Mode of Antiviral Action for Ammonium Ions and Various Amines

Nature volume 207, pages 664–665 (1965)Cite this article

Abstract

AMMONIUM ions and various aliphatic amines have been reported1–4 to inhibit the growth of influenza virus in tissue culture. Recently, 1-adamantanamine was reported5 to inhibit the multiplication of certain strains of influenza virus by slowing or blocking the penetration of virus into the host cells. In this communication we present results showing that ammonium ions and various aliphatic amines inhibit influenza virus growth by the same mechanism as 1-adamantanamine.

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Authors and Affiliations

  1. Experimental Therapeutics Research, Lederle Division, American Cyanamid Co., Pearl River, New York

    R. D. FLETCHER, J. E. HIRSCHFIELD & M. FORBES

Authors
  1. R. D. FLETCHER
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  2. J. E. HIRSCHFIELD
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  3. M. FORBES
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FLETCHER, R., HIRSCHFIELD, J. & FORBES, M. A Common Mode of Antiviral Action for Ammonium Ions and Various Amines. Nature 207, 664–665 (1965). https://doi.org/10.1038/207664a0

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