Abstract
ZINC is a trace metal of physiological importance which is widely distributed in many enzyme systems. Changes in the activity of certain enzymes have been reported in normal and tumour tissues of tumour-bearing animals1 and of man2, and in the serum of patients with neoplastic diseases3–7. Since the activity of some enzymes depends on the presence of specific trace metals, cellular derangement resulting in neoplasia may be linked with changes in trace metal concentration. Differences in zinc concentration in normal and tumour tissue in experimental animals and in man have been previously reported8–15.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Greenstein, J. P., Biochemistry of Cancer, second ed. (Academic Press, New York, 1954).
Dacha, U., Catterina, E., and Fornaini, G., Cancer, 16, 218 (1963).
Bierman, H. R., Hill, B. R., Reinhardt, L., and Emory, E., Cancer Res., 17, 660 (1957).
Moore, A. E., and Wroblewski, F., Proc. Soc. Exp. Biol. and Med., 98, 782 (1958).
Wroblewski, F., Cancer, 12, 27 (1959).
West, M., Schwartz, M. A., Walsh, W. S., and Zimmerman, H. J., Cancer, 15, 931 (1962).
Schwartz, M. A., Walsh, W. S., West, M., and Zimmerman, H. J., Cancer, 15, 927 (1962).
Hoch, F. L., and Vallee, B. L., J. Biol. Chem., 195, 531 (1952).
Heath, J. C., and Liquier-Milward, J., Biochim. Biophys. Acta, 5, 404 (1950).
Tupper, R., Watts, R. W. E., and Wormall, A., Biochem. J., 59, 264 (1955).
Olson, K. B., Heggen, G. E., and Edwards, C. F., Cancer, 11, 554 (1958).
Koch, jun., H. J., and Smith, E. R., J. Clin. Endocrinol. and Metab., 16, 123 (1956).
Ross, J. F., Ebaugh, jun., F. G., and Talbot, jun., T. R., Trans. Assoc. Amer. Physicians, 71, 322 (1958).
Whitmore, jun., W. F., in Biology of the Prostate and Related Tissues, 337 (Nat. Cancer Inst. Mon., No. 12, 1962).
Schrodt, G. R., Hall, T., and Whitmore, jun., W. F., Cancer, 17, 1555 (1964).
Stand, F., Rosoff, B., Williams, G. L., and Spencer, H., J. Pharm. and Exper. Therapeutics, 138, 399 (1962).
Spencer, H., Rosoff, B., Feldstein, A., Cohn, S. H., and Gusmano, E., Rad. Res., 24, 432 (1965).
Vallee, B. L., Physiol. Rev., 29, 443 (1959).
Okunevick, J. P., Schjeide, O. A., Carlsen, E. N., and Hennesy, T. G., Nature, 198, 966 (1963).
Butt, E. M., Nusbaum, R. E., Gilmour, T. C., and DiDio, S. L., in Metal Binding in Medicine, edit. by Seven, M. J., 43 (J. B. Lippincott Co., Philadelphia and Montreal, 1960).
Szmigielski, S., and Litwin, J., Cancer, 17, 1381 (1964).
Author information
Authors and Affiliations
Additional information
For reprints write to Dr. Herta Spencer, Metabolic Section, Veterans Administration Hospital, Hines, Illinois.
Rights and permissions
About this article
Cite this article
ROSOFF, B., SPENCER, H. Tissue Distribution of Zinc-65 in Tumour Tissue and Normal Tissue in Man. Nature 207, 652–653 (1965). https://doi.org/10.1038/207652a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/207652a0
This article is cited by
-
A case-control study on selenium, zinc, and copper in plasma and hair of subjects affected by breast and lung cancer
Biological Trace Element Research (1996)
-
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-Penicillamine
Journal of Neuro-Oncology (1993)
-
Chemical Inactivation in vitro of Carbonic Anhydrase by Carcinogenic Substances
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.