Abstract
RECENTLY, P. S. Gerald et al.1 published their observations on haptoglobin (Hp) in a family with a child in which one of the D group chromosomes (13, 14 or 15) was deformed into a ring structure, which implies that part of the chromosomal material of the chromosome is deleted. It appeared that the carrier of this chromosome lacked the Hp genetical contribution from her father (father, Hp 2-2; mother, Hp 2-1; carrier child, Hp 1-1). Therefore the authors tentatively proposed that the haptoglobin locus is on the end of the long arm of a D chromosome. We had the opportunity to study a number of families with translocations, and our preliminary results are presented as additional information on the localization of Hp.
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References
Gerald, P. S., Warner, S., Singer, J. D., Corcoran, P. A., and Umansky, I., J. Clin. Invest., 43, 1297 (1964).
Hamerton, J. L., Giannelli, F., and Carter, C. O., Cytogenetics, 2, 194 (1963).
Macintyre, M. N., Staples, W. I., Steinberg, A. G., and Hempel, J. M., Amer. J. Hum. Genetics, 14, 335 (1962).
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HUSTINX, T., BIJLSMA, J. & NIJENHUIS, L. Localization of Haptoglobin and ABO. Nature 207, 327–328 (1965). https://doi.org/10.1038/207327b0
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DOI: https://doi.org/10.1038/207327b0
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