Abstract
IN a recent paper Cleaver3 has investigated the uptake of nucleosides by tissue culture cells in physiological saline. From the results he states: “This suggests that the metabolism of these cells is markedly disturbed by brief exposures to a physiological saline and in particular the biosynthesis of the acid-insoluble fractions (for example, DNA and RNA) comes to a standstill. It has been assumed that under these conditions tritiated thymidine is incorporated into DNA and tritiated cytidine is incorporated into both DNA and RNA1,2”.
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References
Seed, J., Proc. Roy. Soc., B, 156, 41 (1962).
Seed, J., Nature, 198, 147 (1963).
Cleaver, J. E., Nature, 206, 401 (1965).
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SEED, J. Nucleoside Incorporation in Animal Cell Cultures. Nature 207, 296 (1965). https://doi.org/10.1038/207296a0
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DOI: https://doi.org/10.1038/207296a0
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