Abstract
WHEN red cells deficient in glucose-6-phosphate (G-6-PD) are incubated with acetylphenylhydrazine under standardized conditions, there is a marked drop in concentration of reduced glutathione (GSH). Under the same conditions, the GSH of normal cells is relatively unaffected1. This procedure, the glutathione stability test, has been widely used in the diagnosis of G-6-PD deficiency2.
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(a) Beutler, E., and Duron, O., J. Lab. and Clin. Med., 62, 860 (1963). (b) Beutler, E., and Duron, O., Transfusion, 5, 17 (1965).
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MATHAI, C., BEUTLER, E. Blood Preservatives for the Glutathione Stability Test. Nature 207, 204–205 (1965). https://doi.org/10.1038/207204a0
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DOI: https://doi.org/10.1038/207204a0
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