Abstract
EVER since the finding that certain of the basal ganglia contain relatively high concentrations of dopamine (3-hydroxytyramine)1,2 there has been a growing interest in the possible role of this amine in the functioning of these structures of the extrapyramidal system3. Hornykiewicz et al. have demonstrated the virtual absence of this amine from the caudate nucleus and putamen of patients dying from Parkinson's disease4,5 and, even though the concentrations of noradrenaline4 and 5-hydroxytryptamine6 in these regions of the brain are substantially below normal values, the decrease in the concentration of dopamine is greater and, in contrast, uninfluenced by administration of monoamine-oxidase inhibitors7.
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SOURKES, T., POIRIER, L. Influence of the Substantia Nigra on the Concentration of 5-Hydroxytryptamine and Dopamine of the Striatum. Nature 207, 202–203 (1965). https://doi.org/10.1038/207202a0
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DOI: https://doi.org/10.1038/207202a0
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Orientierende Übersicht
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie (1966)
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