Abstract
THERE has been considerable interest in the effect of various diets and hormones on liver enzymes. One of the problems related to the interpretation of the results is the dependence upon the method of reporting the data. This problem arises because various treatments cause changes in liver nitrogen content, liver cellularity, body-weight, and ratio of liver-weight to body-weight. Several considerations related to the reporting of results obtained after dietary and hormonal treatment have been discussed previously1–2. It would therefore be interesting if the activity of one enzyme were to remain unaffected by these many treatments using any given method of reporting results. Such an enzyme might be useful as a control. This report will present the effects on the activity of liver sorbitol dehydrogenase activity of several treatments known to affect many liver enzyme activities. Sorbitol dehydrogenase does not appear to be related to any apparently important normal metabolic function of the liver during most regimens or hormonal treatments, and it may therefore serve as a control enzyme activity for most treatments.
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FREEDLAND, R. Rat Liver Sorbitol Dehydrogenase. Nature 207, 192–193 (1965). https://doi.org/10.1038/207192b0
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DOI: https://doi.org/10.1038/207192b0
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