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Polyuridylic Acid Stimulation of Phenylalanine in Human Ribonucleoprotein Particles

Nature volume 207, pages 95–96 (1965)Cite this article

Abstract

THE discovery that synthetic polynucleotides can direct the incorporation into protein of specific amino-acids in cell-free bacterial systems1,2 has been extended to include sub-cellular systems in rat liver3, and mouse plasma cell tumour4, where coding units for amino-acid incorporation were found to be similar to the Escherichia coli system. Weinstein and Schechter4 also reported polyuridylic acid (poly U) stimulation of phenylalanine incorporation into crude cell-free fractions of normal mouse and rat livers, a rat liver tumour, rabbit reticulocytes and a human plasma cell tumour. The experiments reported here support the applicability of this type of study to various human tissues. Poly U was found to stimulate the incorporation of phenylalanine into ribonucleoprotein (RNP) particles of human liver, ovary, lung and prostate. Rat liver RNP preparations are similarly stimulated.

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  1. Department of Pathology, Columbia College of Physicians and Surgeons, New York

    S. SIMBONIS

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  1. S. SIMBONIS
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SIMBONIS, S. Polyuridylic Acid Stimulation of Phenylalanine in Human Ribonucleoprotein Particles. Nature 207, 95–96 (1965). https://doi.org/10.1038/207095a0

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