Abstract
THE presence of 5-hydroxytryptamine (5-HT) in cerebrospinal fluid (CSF) in varied neurological disorders has been reported1–3. Proved cases of leprosy admitted to the local leper hospital provided the samples of CSF for the estimation of the CSF content of 5-HT in leprosy. All cases had some peripheral neuropathy associated with the disease. The 5-HT estimation was done biologically using the oestrogen-primed rat uterus method4. Control values of 5-HT were obtained in CSF collected from 48 normal individuals. Results of 5-HT levels in normal and leprosy cases are given in Table 1. A significantly elevated level of 5-HT was found in all cases of leprosy.
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SINGH, K., MISRA, S. & BHARGAVA, K. 5-Hydroxytryptamine Content of Cerebrospinal Fluid in Leprosy. Nature 206, 206–207 (1965). https://doi.org/10.1038/206206b0
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DOI: https://doi.org/10.1038/206206b0
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