Abstract
IT has been previously reported that incubation of egg lecithin with human plasma produces on the guinea-pig ileum a slow contraction which is, in many respects, indistinguishable from the slow contraction produced by the original plasma1. The slow contracting substance, which is formed in the plasma on incubation with lecithin, can be extracted with alcohol, can be adsorbed on kaolin, and can be precipitated by calcium. It is interesting to note that the amount of egg lecithin which doubles the slow muscle-contracting effect of dialysed plasma is about 250 mg per cent of the plasma, a concentration which roughly corresponds to the concentration of the naturally occurring choline-containing phospholipids in human plasma. This observation suggested an attempt to separate the lipid-soluble slow muscle-contracting substances from human plasma and from the lecithin-plasma incubate which contains 0.25 per cent egg lecithin.
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References
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GABR, Y. Slow Muscle-contracting Substances formed in Egg Lecithin on Incubation with Human Plasma. Nature 206, 201 (1965). https://doi.org/10.1038/206201a0
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DOI: https://doi.org/10.1038/206201a0
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