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Intracellular Location of Tissue Thromboplastin and Possible Relation to Fibrin Deposits in Human Neoplasms

Nature volume 205, pages 608–610 (1965)Cite this article

Abstract

IN 1958 O'Meara and Jackson1, using histochemical techniques, described deposits of fibrin in human malignant neoplasms. Fibrin has been demonstrated also in a number of experimental animal neoplasms by immunological and radioisotopic methods2,3 and in a variety of human malignant neoplasms by the fluorescent antibody technique4. While fibrin may occur in haemorrhagic areas, in blood vessels and in necrotic areas in the vicinity of tumours, it also occurs in the extracellular spaces of tumours.

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Author notes

  1. NOEL CLARKE

    Present address: School of Pathology, Trinity College, Dublin, Ireland

Authors and Affiliations

  1. Laboratory of Experimental Pathology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

    NOEL CLARKE

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  1. NOEL CLARKE
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CLARKE, N. Intracellular Location of Tissue Thromboplastin and Possible Relation to Fibrin Deposits in Human Neoplasms. Nature 205, 608–610 (1965). https://doi.org/10.1038/205608a0

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