Abstract
EARLIER I reported my examinations on variations in the mitotic duration, mitotic count, and mitotic rate after a single surface application of methylcholanthrene to mouse skin1. It was found desirable to continue these studies after repeated paintings inasmuch as continuous painting is followed by hyperplasia and tumour formation, and the present communication concerns an investigation of the mitotic rate during a period of additional and excessive growth. Hairless mice (hr/hr) were painted 3 times weekly with 0.6 per cent solution of methylcholanthrene in benzene. Each week one group of eight mice was killed, the last group 13 weeks after the first application. Mitoses were counted, the mitotic duration was estimated by the ‘Colcemid’ method, and the rate calculated according to the equation: (mitotic duration) × (mitotic rate) = mitotic count (ref. 2).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Elgjo, K., Nature, 200, 608 (1963).
Leblond, P., and Bruce, E. W., Physiol. Rev., 36, 255 (1956).
Evensen, A., and Iversen, O. H., Nature, 196, 383 (1962).
Iversen, O. H., and Evensen, A., Acta Path. et Microbiol. Scand., Suppl., 156 (1962).
Fischer, A., and Parker, R. C., Brit. J. Exp. Path., 20, 312 (1929).
von Moellendorff, W., Z. Zellforsch., 31, 60 (1941).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ELGJO, K. Kinetics of Cellular Growth after Repeated Applications of Methylcholanthrene. Nature 205, 407–408 (1965). https://doi.org/10.1038/205407b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/205407b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.