Abstract
COLLIER et al.1 reported in 1959 that partially purified natural bradykinin, made by incubating trypsin with ox globulin, causes bronchoconstriction when injected into guinea-pigs. This action was confirmed for the synthetic nonapeptide2,3 as well as for the decapeptide kallidin4 and the endecapeptide eledoisin5. In contrast to the bronchoconstrictor action of serotonin and histamine, the effect of bradykinin and kallidin was completely abolished by pretreatment with acetylsalicylic acid and phenylbutazone1,4.
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GJURIS̆, V., WESTERMANN, E. Bronchoconstrictor Action of Bradykinin, Kallidin and Eledoisin. Nature 205, 402–403 (1965). https://doi.org/10.1038/205402a0
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DOI: https://doi.org/10.1038/205402a0
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