Abstract
HEATHCOTE and Mooney1 reported in this journal their clinical results from treating two cases of pernicious anaemia with a vitamin B12 glutamic acid mixture, and we published2 our own results of Schilling tests with and without L-glutamic acid in patients with pernicious anaemia. Our results showed that glutamic acid does not in general increase the absorption of vitamin B12 measured by the Schilling test. In their reply3 Mooney and Heathcote disregarded our results, doubting whether the Schilling test has in fact any physiological merit at all. Although we cannot concur in their opinion of the Schilling test, we decided to investigate the problem from another aspect as well.
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References
Heathcote, J. G., and Mooney, F. S., Nature, 193, 380 (1962).
Heinivaara, O., and Palva, I., Nature, 199, 289 (1963).
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Bethel, F. H., Meyers, M. C., and Neligh, R. B., J. Lab. Clin. Med., 33, 477 (1948).
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PALVA, I., HEINIVAARA, O. Oral Treatment of Pernicious Anaemia. Nature 205, 393 (1965). https://doi.org/10.1038/205393a0
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DOI: https://doi.org/10.1038/205393a0
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