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5-Hydroxytryptamine Receptors and Synaptic Transmission in Molluscan Neurones

Abstract

Welsh and Moorhead1 found large amounts of 5-hydroxytryptamie (5-HT) in the nervous system of different classes of molluscs and postulated its possible role as a transmitter. More recently the presence of 5-HT in land-snail nervous tissue was confirmed by Kerkut and Cottrell2 and by Cardot and Ripplinger3. The interest of this finding was stressed by Ersparmer4, who pointed out that “a thorough study of the 5-HT in the nervous tissue of Molluscs may offer a key to a better understanding of the function of the amine in the brain of Vertebrates”.

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References

  1. Welsh, J. H., and Moorhead, M., J. Neurochem., 6, 146 (1960).

    Article  CAS  Google Scholar 

  2. Kerkut, G. A., and Cottrell, G. A., Comp. Biochem. Physiol., 8, 53 (1963).

    Article  CAS  Google Scholar 

  3. Cardot, J., and Ripplinger, J., J. Physiol. (Paris), 55, 217 (1963).

    CAS  Google Scholar 

  4. Ersparmer, V., Prog. Drug Res., 2, 151 (1961).

    Google Scholar 

  5. Gerschenfeld, H. M., and Tauc, L., Nature, 189 924 (1961).

    Article  CAS  ADS  Google Scholar 

  6. Tauc, L., C.R. Acad. Sci., Paris, 249, 318 (1959).

    CAS  Google Scholar 

  7. Gerschenfeld, H. M., and Tauc, L., J. Physiol., Paris (1964).

  8. Katz, B., and Thesleff, S., J. Physiol., London, 138, 37 (1957).

    Article  Google Scholar 

  9. Tauc, L., and Bruner, J., Nature, 198, 33 (1963).

    Article  CAS  ADS  Google Scholar 

  10. Gerschenfeld, H. M., and Lasansky, A., Intern. J. Neuropharmacol., 3, 301 (1964).

    Article  CAS  Google Scholar 

  11. Gyermek, L., Pharmacol. Revs., 13, 399 (1961).

    CAS  Google Scholar 

  12. Rodriguez de Lores Arnaiz, G., and De Robertis, E., J. Neurochem., 9, 503 (1962).

    Article  CAS  Google Scholar 

  13. van Rossum, J. M., Arch. Intern. Pharmacodyn., 143, 299 (1963).

    CAS  Google Scholar 

  14. Ariens, E. J., and Simonis, A. M., J. Pharm. Pharmacol., 16, 289 (1964).

    Article  CAS  Google Scholar 

  15. Zieher, L. M., and Gerschenfeld, H. M. (unpublished results).

  16. Welsh, J. H., and Moorhead, M., Gunma J. Med. Sci., 8, 211 (1959).

    CAS  Google Scholar 

  17. Cardot, J., C.R. Acad. Sci., Paris, 256, 236 (1963).

    Google Scholar 

  18. Cardot, J., C.R. Acad. Sci., Paris, 258, 1103 (1964).

    CAS  Google Scholar 

  19. Gaddum, J. H., J. Physiol., 121, 15P (1957).

    Google Scholar 

Download references

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GERSCHENFELD, H., STEFANI, E. 5-Hydroxytryptamine Receptors and Synaptic Transmission in Molluscan Neurones. Nature 205, 1216–1218 (1965). https://doi.org/10.1038/2051216a0

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