Abstract
MUCH recent work has indicated that in tissues with a high secretory or nervous activity the rate of aerobic metabolism may be determined by the activity of the ion transport mechanism. This control is effected through the levels of ADP and ATP in the cell, which vary according to the activity of the sodium–potassium stimulated ATPase, the enzyme which governs sodium transport1. It has been shown that ouabain, a specific inhibitor of sodium–potassium ATPase, causes a 40 per cent decrease in the rate of oxygen uptake in kidney2 and in liver3 and a 30 per cent decrease in brain4.
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RILEY, M. Inhibition by Ouabain of Glycolysis in Ciliary Body. Nature 204, 380 (1964). https://doi.org/10.1038/204380a0
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DOI: https://doi.org/10.1038/204380a0
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