Abstract
How aspirin exerts its analgesic action has been much discussed. The findings here reported suggest that it depresses certain chemonociceptive responses at or near their peripheral source, rather than in the central nervous system, and that it acts on these directly, rather than indirectly through suppressing œdema formation.
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COLLIER, H., HAMMOND, A., HORWOOD-BARRETT, S. et al. Rapid Induction by Acetylcholine, Bradykinin and Potassium of a Nociceptive Response in Mice and its Selective Antagonism by Aspirin. Nature 204, 1316–1318 (1964). https://doi.org/10.1038/2041316b0
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DOI: https://doi.org/10.1038/2041316b0
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