Abstract
THE good state of health of cats deprived of the whole length of their paravertebral sympathetic chains and a part of the prevertebral (cœliac and mesenteric) ganglia is well known since the work of Cannon1. In contrast, removal of the prevertebral ganglia is not well tolerated in dogs, which do not survive this operation because of intractable diarrhœa2. ‘Immunosympathectomized’ rats, in which extensive irreversible atrophy of the peripheral sympathetic system is produced by injecting, during the first few days of life, an antiserum to the nerve growth factor described by Levi-Montalcini and Booker3, appear healthy, grow, reproduce and have normal gastrointestinal function4.
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References
Cannon, W. B., The Wisdom of the Body (London: Kegan Paul, 1932).
Verney, E. B., and Vogt, M., Quart. J. Exp. Physiol., 28, 253 (1938).
Levi-Montalcini, R., and Booker, B., Proc. U.S. Nat. Acad. Sci., 46, 373, 384 (1960).
Zaimis, E., J. Physiol. (in the press).
Carpi, A., and Oliverio, A., Intern. J. Neuropharmacol., 17, 427 (1964).
Lempinen, M., Acta Physiol. Scand., 62, Supp. 231, 1 (1964).
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VOGT, M. Sources of Noradrenaline in the ‘Immunosympathectomized’ Rat. Nature 204, 1315–1316 (1964). https://doi.org/10.1038/2041315a0
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DOI: https://doi.org/10.1038/2041315a0
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