Abstract
IN bacteria certain genetic determinants which may be gained or lost can multiply without incorporation in the bacterial chromosome. Some such plasmids1, the class of episomes2, may become reversibly integrated into the chromosome; for others, including the transmissible drug-resistance (R) factors3, integration has not been unequivocally demonstrated. We report observations on the transmission of an R factor and of colicine factors by conjugation and transduction in Salmonella typhimurium, and show that R factor genetic material may become attached to the bacterial chromosome—but only by becoming associated with an episome, prophage P22.
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DUBNAU, E., STOCKER, B. Genetics of Plasmids in Salmonella typhimurium. Nature 204, 1112–1113 (1964). https://doi.org/10.1038/2041112a0
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DOI: https://doi.org/10.1038/2041112a0
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