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Solubility of Fibrin Clots in Solutions of Heparin

Abstract

HEPARIN has been shown to retard both the beginning and the general course of polymerization of purified fibrinogen1. Evidence will be presented that this anticoagulant, in solutions of low ionic strength, in addition to inhibiting the polymerization of fibrinogen, is able to depolymerize and thus dissolve preformed clots.

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References

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TRIANTAPHYLLOPOULOS, D., TRIANTAPHYLLOPOULOS, E. Solubility of Fibrin Clots in Solutions of Heparin. Nature 204, 1096–1098 (1964). https://doi.org/10.1038/2041096b0

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