Abstract
DURING a longitudinal investigation of the changes with age in steroid excretion in healthy children, we have found a new steroid substance1. It was present in 11 out of 19 healthy children aged 8–12 years; in all of 7 healthy 3-year-old children; and in none of about 100 adult men and non-pregnant women. Twelve of the 8–12-year-old children have been examined repeatedly at six-monthly intervals, for 18 months–2 years. Six were initially excretors and six non-excretors, and none showed any change in status. Four adults with Cushing's syndrome were all non-excretors, but both of two pregnant women tested excreted the substance. Two children with the rare disease of lipodystrophy and accelerated growth and one 3-year-old child with progeria showed a markedly greater excretion than anybody else we have seen.
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GUPTA, D., TANNER, J. A New Steroid found in the Urine of Children but not Adults. Nature 203, 187–188 (1964). https://doi.org/10.1038/203187a0
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DOI: https://doi.org/10.1038/203187a0
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