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Nicotinic Acid-excreting Mutants in Chlamydomonas

Nature volume 202, pages 826–827 (1964)Cite this article

Abstract

ADELBERG1 has developed a valuable method for obtaining mutants of Escherichia coli, which synthesize substantial amounts of amino-acids, based on the selection for resistance to substances antagonistic to the desired metabolite. The investigation of such mutants promises to provide information about the mechanisms of control of biosynthesis and of drug resistance. This communication reports the extension of this method to a vitamin, and to an organism (the unicellular green alga Chlamydomonas eugametos) which has a sexual life-cycle allowing detailed genetic investigations by means of tetrad analysis2.

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References

  1. Adelberg, E. A., J. Bact., 76, 326 (1958).

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  2. Gowans, C. S., Z. Vererb.-Lehre, 91, 63 (1960).

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  3. Barton-Wright, E. C., The Microbiological Assay of the Vitamin B-complex and Amino Acids, 46 (Pitman, New York, 1952).

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  4. Nakamura, K., and Gowans, C. S. (unpublished results).

  5. Scherr, G. H., and Rafelson, jun., M. E., J. App. Bact., 25, 187 (1962).

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Authors and Affiliations

  1. Department of Botany, University of Missouri, Columbia

    KAZUO NAKAMURA & C. SHIELDS GOWANS

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  1. KAZUO NAKAMURA
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  2. C. SHIELDS GOWANS
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NAKAMURA, K., GOWANS, C. Nicotinic Acid-excreting Mutants in Chlamydomonas. Nature 202, 826–827 (1964). https://doi.org/10.1038/202826a0

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