Abstract
THERE have been many reports concerning the relations between nucleic acid metabolism and adrenocortical hormones. But there are only a few data concerning the mechanism by which the adrenal glucocorticoid hormones (and ACTH) influence mitosis1. Cortisone has been found to lessen hepatic regeneration2, probably through an antimitotic action on regenerating liver3. It has also been demonstrated that ACTH, cortisone and dehydrocortisone inhibit the formation of granulation tissue4,5. However, the mechanism by which corticoids influence the metabolism of proteins4 and that of the nucleic acids is not yet known.
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GUZEK, J. Effect of Adrenocorticotrophic Hormone and Cortisone on the Uptake of Tritiated Thymidine by Regenerating Liver Tissue in the White Rat. Nature 201, 930–931 (1964). https://doi.org/10.1038/201930a0
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DOI: https://doi.org/10.1038/201930a0
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