Abstract
IN a previous communication, I reported that the formation of carbonyl chloride in a state of high blood urea-level associated with acidæmia is responsible for uræmic coma. It was also claimed that phosgene is not formed under normal conditions in blood due to the absence of biologically available urea and acidæmia. Since then, investigations from different aspects have been pursued to confirm that uræmia is attributable to the formation of phosgene as claimed by the author. The results have lead to some additional direct evidences which are reported here.
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References
Sen, D. K., Nature, 193, 889 (1962).
The Merck Index of Chemicals and Drugs (Merck and Co., Inc., New Jersey, 1952).
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SEN, D. Phosgene Formation in Uræmia. Nature 201, 1334 (1964). https://doi.org/10.1038/2011334a0
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DOI: https://doi.org/10.1038/2011334a0
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