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Nature of Prothrombin Biosynthesis : Preprothrombinæmia in Vitamin K-deficiency

Nature volume 200, pages 589–590 (1963)Cite this article

Abstract

THE activities of the clotting factors II, VII, IX, and X are mutually lowered to a similar degree in chronic hepatic damage as well as during prolonged real or relative (coumar in-induced) vitamin K-deficiency1,2. In the experiments described here, Owren's thrombotest (slightly modified, Fig. 1) is used for the assessment of the extent of depression. Each plasma sample is tested in a series of dilutions (D) and the coagulation time (t, mean of 4 readings) measured in a coagulometer3,4. All plasmas and plasma dilutions are kept in carefully siliconized glassware or plastic material. When t is plotted against D, a straight line is obtained (Fig. 1).

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References

  1. Loeliger, E. A., van der Esch, B., Mattern, M. J., and den Brabander, A. S. A., Thrombos. Diathes. Hæmorrh., 9, 74 (1963).

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  2. Loeliger, E. A. (unpublished results).

  3. Schnitger, H., and Gross, R., Klin. Wschr., 32, 1011 (1954).

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  4. Schnitger, H., M.D. thesis, Marburg (1956).

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  6. Hemker, H. C., Veltkamp, J. J., Hensen, A., and Loeliger, E. A., Trans. Conf. Intern. Comm. Blood Clotting Factors, 1963 (F. K. Schattauer-Verlag, Stuttgart; in the press).

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Authors and Affiliations

  1. Hæmatology Section, Department of Internal Medicine, University Hospital, Leyden

    H. C. HEMKER, J. J. VELTKAMP, A. HENSEN & E. A. LOELIGER

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  1. H. C. HEMKER
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  2. J. J. VELTKAMP
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  3. A. HENSEN
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  4. E. A. LOELIGER
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HEMKER, H., VELTKAMP, J., HENSEN, A. et al. Nature of Prothrombin Biosynthesis : Preprothrombinæmia in Vitamin K-deficiency. Nature 200, 589–590 (1963). https://doi.org/10.1038/200589a0

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