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Histamine-binding Action of Lysergic Acid Diethylamide

Nature volume 200, pages 582–583 (1963)Cite this article

Abstract

WE have previously reported1 the effect of lysergic acid diethylamide (LSD-25) on the levels of serotonin in the rabbit. These results showed increased levels of serotonin in all parts of the body, except in the cerebrum, of the rabbit after administration of LSD-25. Freedinan and Giarman2 showed increased levels of serotonin in cell partieulate matter in animals treated with LSD-25. These results denote that, while LSD-25 is somehow increasing the levels of serotonin, it is also increasing the binding of serotonin into an inactive or bound form. Our later work3 showed that LSD-25 decreased the levels of norepinephrine in the rabbit, probably by releasing norepinephrine from a bound form, not susceptible to enzymatic action, to a free form subject to further enzymatic catabolism.

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References

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Authors and Affiliations

  1. Biochemical Research Laboratory, Children's Unit, Creedmoor State Hospital, Jamaica, 27, New York

    D. V. SIVA SANKAR, HENRY H. BROER & NORMAN GATES

Authors
  1. D. V. SIVA SANKAR
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  2. HENRY H. BROER
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  3. NORMAN GATES
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SANKAR, D., BROER, H. & GATES, N. Histamine-binding Action of Lysergic Acid Diethylamide. Nature 200, 582–583 (1963). https://doi.org/10.1038/200582a0

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