Abstract
THERE is general agreement that 5-hydroxytryptamino (5HT) is formed from 5-hydroxytryptophan (5HTP) in the presence of 5-hydroxytryptophan decarboxylase (5HTPD). It is then oxidized to 5-hydroxy indolylacetic acid (5HIAH) with monoamine oxidase (MAO). A decrease of brain 5HT has been reported in new-born animals1,2 and those made phenylketonurie by means of a diet high in phenylalanine content3,4. In this communication investigations of the differing mechanisms responsible for this decrease are described.
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HSIA, DY., NISHIMURA, K. & BRENCHLEY, Y. Mechanisms for the Decrease of Brain Serotonin. Nature 200, 578 (1963). https://doi.org/10.1038/200578a0
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DOI: https://doi.org/10.1038/200578a0
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