Abstract
WE have previously reported that the level of cysta-thionase (‘soluble’ cysteine desulphurase) of rat liver is increased when L-methionine is injected in male rats maintained on a commercial diet1. We have recently shown that a similar increase could be obtained with rats placed on a synthetic diet (diet B) containing 18 per cent casein; furthermore, the level of cystathionase is higher in liver of rats maintained on a synthetic diet (diet C) containing 60 per cent casein, and we have observed that addition of a definite quantity of DL-methionine to diet B increases the enzyme-level2. These results indicate that some correlation could be established between dietary protein and the level of enzyme activity, and suggest that ‘adaptation’ of cystathionase is mediated, at least in part, by the content of methionine in the diet. As the increase in enzyme activity found on varying methionine intakes could be the reflexion of alteration of the content of specific protein in the liver, in the investigation described here we have determined the effect of addition of DL-ethionine (S-ethyl/analogue of methionine) to the diets on the level of hepatic cystathionase.
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Chatagner, F., and Trautmann, O., Nature, 194, 1281 (1962).
Trautmann, O., and Chatagner, F., Bull. Soc. Chim. Biol. (in the press).
Chatagner, F., Jollès-Bergeret, B., and Labouesse, J., C.R. Acad. Sci., Paris, 251, 3097 (1960).
Jollès-Bergeret, B., Labouesse, J., and Chatagner, F., Bull. Soc. Chim. Biol., 42, 51 (1960).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Farber, E., and Corban, M. S., J. Biol. Chem., 233, 625 (1958).
Shen, C. W., and Lewis, H. B., J. Biol. Chem., 165, 115 (1946).
Natori, Y., J. Biol. Chem., 238, 2075 (1963).
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CHATAGNER, F., TRAUTMANN, O. Effect of DL-Ethionine on the Level of Cystathionase in Rat Liver. Nature 200, 75 (1963). https://doi.org/10.1038/200075a0
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DOI: https://doi.org/10.1038/200075a0
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