Abstract
IT has been shown that the fowl plague virus, which belongs to the influenza A group, can be inactivated by an ethylene-iminoquinone (Bayer A 139, a gift of the Bayer-Werke, Leverkusen, Germany)1 or by hydroxylamine2,3 without losing its antigenic, neuraminidase, or hæmagglutinating activities. Bayer A 139 mainly reacts with the phosphate groups of nucleic acids, and in this way the sugar-phosphate ‘backbone’ is broken4,5. Hydroxylamine attacks the pyrimidines of the nucleic acids without breaking the RNA-strand6. Since during inactivation of the fowl plague virus with both compounds a phenomenon interpreted as multiplicity reactivation was observed1,3, one should still expect viral RNA-synthesis in cells which were infected with partially or totally inactivated virus. Experiments designed to clarify this point are described here.
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SCHOLTISSEK, C., ROTT, R. Synthesis of Viral Ribonucleic Acid by a Chemically Inactivated Influenza Virus. Nature 199, 200–201 (1963). https://doi.org/10.1038/199200a0
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DOI: https://doi.org/10.1038/199200a0
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