Abstract
PHYTOHÆMAGGLUTININ, an extract containing mucoprotein obtained from the bean, Phaseolus vulgaris, has been shown to cause active transformation of lymphocytes in human peripheral blood tissue cultures. These cells enlarge, actively synthesize DNA and then show considerable mitotic activity1,2. However, injection of the Difco M form of phytohæmagglutinin by various routes into young female Wistar rats did not produce unequivocal evidence of lymphoproliferation3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nowell, P. C., Cancer Res., 20, 462 (1960).
Cooper, E. H., Barkhan, P., and Hale, A. J., Brit. J. Hæmat., 9, 101 (1963).
Elves, M. W., Roath, S., and Israels, M. C. G., Nature, 198, 494 (1963).
Yoffey, J. M., Quantitative Cellular Hæmatology (Charles C. Thomas, Springfield, Ill., 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUMBLE, J. In vivo Action of Phytohæmagglutinin in Severe Human Aplastic Anæmia. Nature 198, 1313–1314 (1963). https://doi.org/10.1038/1981313a0
Issue Date:
DOI: https://doi.org/10.1038/1981313a0
This article is cited by
-
Use of phytohemagglutinin in the treatment of maxillary cancer
Archives of Oto-Rhino-Laryngology (1980)
-
Phytomitogens and lymphocyte blastogenesis
In Vitro (1969)
-
Cell Viability in Leucocyte Cultures stimulated with Phytohaemagglutinin
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
