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Incubation of Serum with Tissue Extracts as a Cause of Chemotaxis of Granulocytes

Abstract

USING a new technique, Boyden1 has shown that rabbit serum after incubation in vitro with an antigen-antibody precipitate becomes strongly chemotactic to rabbit granulocytes. Prior heating of the serum to 56° for 30 min was found to prevent activation of the chemotactic principle which, once formed, was relatively heat-stable.

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References

  1. Boyden, S., J. Exp. Med., 115, 453 (1962).

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  2. Hurley, J. V., and Spector, W. G., J. Path. Bact., 82, 403 (1961).

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  3. Hurley, J. V., and Spector, W. G., J. Path. Bact., 82, 421 (1961).

    Article  CAS  Google Scholar 

  4. Harris, H., J. Path. Bact., 66, 135 (1953).

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HURLEY, J. Incubation of Serum with Tissue Extracts as a Cause of Chemotaxis of Granulocytes. Nature 198, 1212–1213 (1963). https://doi.org/10.1038/1981212a0

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